METHOD OF ASSESSING IMMEDIATE RESULTS OF TREATMENT OF PATIENTS WITH DISSEMINATED FORMS OF MALIGNANT TUMORS Russian patent published in 2023 - IPC G01N33/68 G01N33/574 

FIELD: medicine; oncology.

SUBSTANCE: invention can be used to assess the sensitivity of a tumor to immuno-oncological medicinal products. The level of spontaneous production of IL-8 (IL-8-KR1, IL-8-M) and IL-10 (IL-10-KR1, IL-10-M) and induced production of IL-12 (IL-12-KP1, IL-12-M) is determined in the patient’s blood (CR) and in the tumor microenvironment (M) before the start of each cycle of treatment with immuno-oncological medicinal products, and the same parameters are also evaluated in the blood (IL-8-KP2, IL-10-KP2, IL -12-KR2) after each treatment cycle. Based on the values obtained, the following coefficients are calculated:

K1= IL-8-M/ IL-8-KP1 - IL-8-M/ IL-8-KP2;

K2 = IL-10-M/ IL-10-KP1 - IL-10-M/ IL-10-KP2;

K3 = IL-12-M/ IL-12-KP2 - IL-12-M/ IL-12-KP1. If the value of at least one of the coefficients is equal to or higher than 1.7, this is regarded as an early sign of progression.

EFFECT: method provides the opportunity to increase the accuracy of assessing the immediate results of treatment of patients with disseminated forms of malignant tumors through the use of immunological parameters of the blood and microenvironment.

1 cl, 8 tbl