METHOD OF ASSESSING THE EFFICIENCY OF ANTI-CLEGGANT MEDICINAL PRODUCT IN WHOLE PERIPHERAL BLOOD SAMPLES Russian patent published in 2023 - IPC G01N33/50 G01N33/96 

FIELD: medicine.

SUBSTANCE: invention relates to a method of evaluating the effectiveness of an antiplatelet medicinal product in samples of whole peripheral blood. A method is proposed for evaluating the effectiveness of an antiplatelet medicinal product in samples of whole peripheral blood by determining platelet-monocyte complexes (PMC), according to the invention, the level of ADP-induced PMC is determined in a blood sample without and in the presence of the tested antiplatelet medicinal product and if the level of ADP-induced PMC in the presence of the medicinal product is higher than without it, then the antiplatelet medicinal product is considered ineffective, if the level of ADP-induced PMC in the presence of the medicinal product is lower than without it, or remains at the initial level, then the antiplatelet medicinal product is considered effective.

EFFECT: above invention allows to increase the objectivity of the assessment, makes it possible to integrally assess its effect on the hemostasis system, taking into account the different mechanism of their action, the ability to evaluate not only the effect of the test medicinal product on platelets, but also its possible effects on intercellular interactions that characterize the direct participation of cells in hemostatic reactions.

1 cl, 8 dwg, 2 ex