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2 802 003

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IPC

C07D487/12(2006-01-01)

A61K31/4188(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2022134694, 2022-12-28

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Start date

2022-12-28

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Actual filing date

2022-12-28

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Published

2023-08-22

(72)

Inventor

Baibakova Olga VladimirovnaEremina Valeriia ValerevnaKulagina Daria AleksandrovnaAlekseeva Natalia AlekseevnaSysoliatin Sergei Viktorovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Problem Khimiko-Energeticheskikh Tekhnologij Sibirskogo Otdeleniya Rossijskoj Akademii Nauk So Ran)

4-(3,4-DIBROMOTHIOPHENECARBONIL)-2,6,8,12-TETRAACETIL-2,4,6,8,10,12-HEXAAZATETRACYCLO[5,5,0,0,0]DODECANE DERIVATIVES WITH SALICYLIC ACIDS AS ANALGESICS AND METHOD FOR THEIR PRODUCTION Russian patent published in 2023 - IPC C07D487/12 A61K31/4188 A61P29/00

Abstract RU 2802003 C1

FIELD: organic chemistry.

SUBSTANCE: 4-(3,4-dibromothiophenecarbonyl)-10-(2-hydroxybenzoyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaaza- tetracyclo[5,5,0,0^3.11,0^5.9] dodecane, 4-(3,4-dibromothiophenecarbonyl)-10-(2-acetyloxy-benzoyl)-2,6,8,12-tetraacetyl- 2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0^3.11,0^5.9] dodecane and method for their production. The method is carried out by acylation of 4-(3,4-dibromothiophenecarbonyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo-[5,5,0,0^3,11, 0^5.9]dodecane with 2-hydroxybenzoyl chloride or 2-acetyloxybenzoyl chloride, respectively.

EFFECT: 4-(3,4-dibromothiophenecarbonyl)-10-(2-hydroxybenzoyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0^3.11,0^5.9]-dodecane and 4-(3,4-dibromothiophenecarbonyl)-10-(2-acetyloxybenzoyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0^3.11,0^5.9] dodecane with analgesic activity.

3 cl, 2 tbl, 3 ex

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RU 2 802 003 C1

Authors

Baibakova Olga Vladimirovna

Eremina Valeriia Valerevna

Kulagina Daria Aleksandrovna

Alekseeva Natalia Alekseevna

Sysoliatin Sergei Viktorovich

Dates

2023-08-22—Published

2022-12-28—Filed