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2 834 298

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IPC

C07D487/22(2006-01-01)

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Application

2023135463, 2023-12-27

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Start date

2023-12-27

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Actual filing date

2023-12-27

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Published

2025-02-05

(72)

Inventor

Eremina Valeriia ValerevnaKulagina Daria AleksandrovnaAlekseeva Natalia AlekseevnaSysoliatin Sergei Viktorovich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Nauki Institut Problem Khimiko-Energeticheskikh Tekhnologii Sibirskogo Otdeleniia Rossiiskoi Akademii Nauk So Ran)

ONE-POT METHOD OF PRODUCING 4,10-DI(2-ETHOXYACETYL)-2,6,8,12-TETRAACETYL-2,4,6,8,10,12-HEXAAZATETRACYCLO[5,5,0,0,0]DODECANE Russian patent published in 2025 - IPC C07D487/22

Abstract RU 2834298 C1

FIELD: chemistry.

SUBSTANCE: disclosed is an improved method of producing 4,10-di(2-ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0^3,11,0^5.9]dodecane, which is used as an analgesic. Method is characterized by that it involves chlorination of 2-ethoxyacetic acid with thionyl chloride in 1,2-dichloroethane and subsequent, without separation of steps, acylation of 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0^3,11,0^5,9]dodecane with freshly obtained 15 % molar excess acid chloride 2-ethoxyacetic acid in 1,2-dichloroethane.

EFFECT: providing a simplified method of producing a target compound.

1 cl, 1 ex

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RU 2 834 298 C1

Authors

Eremina Valeriia Valerevna

Kulagina Daria Aleksandrovna

Alekseeva Natalia Alekseevna

Sysoliatin Sergei Viktorovich

Dates

2025-02-05—Published

2023-12-27—Filed