METHOD OF PREDICTING THE DEVELOPMENT OF OCCUPATIONAL CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PERSONS WORKING UNDER CONDITIONS OF EXPOSURE TO INDUSTRIAL AEROSOLS CONTAINING NANOPARTICLES WITH SILICON Russian patent published in 2023 - IPC G01N33/68 G01N33/52 G16H50/30 

FIELD: medicine; occupational medicine; pulmonology.

SUBSTANCE: invention can be used to predict the development of occupational chronic obstructive pulmonary disease (OCOPD). The forecast is carried out for the next 3 years in relation to patients who do not have respiratory diseases, who have worked for 5 years or more under the influence of industrial aerosols containing unintentional silicon nanoparticles. In the peripheral blood of the patient, the proportion of the subpopulation of non-classical monocytes CD14^DimCD16+ is determined relative to all monocytes. In blood serum, the concentrations of fibroblast growth factor-2 (FGF-2), soluble vascular adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9) and N-terminal type 3 procollagen propeptide (PIIINP) are determined. The logistic regression equation is solved. If the value of the solution of the equation is 0.364 or more, a high risk of development of OCOPD in a patient in the next 3 years is predicted. When the value of the solution of the equation is less than 0.364, a low risk of development of OCOPD is predicted.

EFFECT: method makes it possible to predict the development of OCOPD within 3 years by determining in the blood of patients a complex of cellular and biochemical parameters associated with the risk of development of OCOPD under the influence of nanoparticles with silicon.

1 cl, 1 dwg, 8 tbl, 4 ex