FIELD: molecular biology.
SUBSTANCE: method for predicting the risk of developing severe bronchial asthma (SBA) is described. Genotyping of polymorphic loci rs896 of the vasointestinal peptide receptor gene, rs2072100 of the substance P gene, rs3771829 of the substance P receptor gene, rs3823082 of the vasointestinal peptide gene is carried out. The probability of developing TBA is determined taking into account the coefficient of the genotype of each polymorphic locus according to the equation of logistic regression. With a probability value of 0.57 or more, a high risk of developing severe bronchial asthma is predicted.
EFFECT: use of the invention provides an increase in the accuracy of the forecast by obtaining criteria for the risk of developing SBA at the earliest stages of the development of the disease.
1 cl, 1 tbl, 8 ex
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