FIELD: biotechnology.
SUBSTANCE: neoantigen expression system containing one or more vectors, and one or more vectors contain: Alphavirus RNA backbone, wherein the alphavirus RNA backbone contains alphavirus RNA backbone sequences that allow for self-replication of the viral genome, a pharmaceutical composition and uses thereof for treating cancer and for stimulating an immune response in a subject.
EFFECT: present inventions can be effectively used as vaccines.
23 cl, 38 dwg, 31 tbl
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| COMPOSITIONS OF VACCINES AGAINST NEOPLASIA AND METHODS FOR OBTAINING THEREOF | 2016 |
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RU2753246C2 |
| T-CELL RECEPTOR CONSTRUCTS AND THEIR USE | 2019 |
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RU2785954C2 |
| PREDICTION OF IMMUNOGENICITY OF T-CELL EPITOPES | 2014 |
|
RU2724370C2 |
| NEOANTIGENS AND THEIR APPLICATION | 2019 |
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RU2805196C2 |
| NEOANTIGENS AND THEIR APPLICATION METHODS | 2017 |
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RU2773273C2 |
| NEOANTIGENS AND THEIR USE | 2019 |
|
RU2813924C2 |
| FUSION CONSTRUCTION CONTAINING CELL PENETRATING PEPTIDE, POLYEPITOPE AND TLR PEPTIDE AGONIST, INTENDED FOR TREATMENT OF CANCER | 2017 |
|
RU2807135C2 |
| VACCINE COMPOSITION FOR TREATMENT OF CANCER | 2018 |
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RU2782261C2 |
| PERSONALIZED VACCINE | 2018 |
|
RU2779987C2 |
| ANTIBODY-DRUG CONJUGATES CONTAINING HERBOXYDIENE-BASED SPLICING MODULATOR, AND METHODS OF USE THEREOF | 2019 |
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RU2820607C2 |
