FIELD: medicine.
SUBSTANCE: method for treating amyotrophic lateral sclerosis. To do this, in a mouse model, a single retro-orbital transplantation of induced microvesicles obtained by treating one million mesenchymal stem cells of human adipose tissue with cytochalasin B is carried out.
EFFECT: increase in life expectancy, relief of motor symptoms, correction of the processes of exo-endocytosis of synaptic vesicles in motor nerve endings, reduction of neuroinflammation in the spinal cord in a model of amyotrophic lateral sclerosis.
1 cl, 4 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| GENE-CELL VESICULAR THERAPEUTIC DRUG AND METHOD FOR MULTIPLE SCLEROSIS THERAPY BY TRANSPLANTATION OF A GENE-CELL VESICULAR THERAPEUTIC DRUG | 2021 |
|
RU2762855C1 |
| METHOD FOR PREDICTING THE DEVELOPMENT OF FUS-ASSOCIATED NEURODEGENERATIVE DISORDERS IN MICE | 2021 |
|
RU2755768C1 |
| METHOD FOR SPINAL CORD REGENERATION STIMULATION BY MEANS OF VESICLES PREPARED FROM MESENCHYMAL STEM CELLS OF ADIPOSE TISSUE | 2020 |
|
RU2739912C1 |
| AGENT FOR REPRESSION OF DEATH OF NEURONS IN ISCHEMIC STROKE OF BRAIN AND METHOD OF CELL-MEDIATED GENE THERAPY FOR ISCHEMIC STROKE OF BRAIN BY REPRESSION OF DEATH OF NEURONS IN ISCHEMIC STROKE OF BRAIN | 2017 |
|
RU2676701C1 |
| METHOD OF PRODUCING A MEDICINAL PREPARATION BASED ON HUMAN CELL VESICLES | 2015 |
|
RU2605853C1 |
| METHOD FOR INCREASING THE PROLIFERATIVE POTENTIAL OF THREE-DIMENSIONAL TUMOR CELL CULTURES | 2021 |
|
RU2782600C1 |
| FLUORINE-CONTAINING SUBSTITUTED 5-[2-(PYRID-3-YL)-ETHYL]-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-b]INDOLE HYDROCHLORIDES AS AGENTS DECREASING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM, BASED PHARMACEUTICAL PREPARATION AND METHOD OF USING IT | 2011 |
|
RU2490268C2 |
| METHOD FOR OBTAINING BIOMEDICAL CELL PRODUCT FOR TREATMENT OF ONCOLOGICAL, NEURODEGENERATIVE AND AUTOIMMUNE DISEASES | 2019 |
|
RU2774350C2 |
| USING MESENCHYMAL AND NEURONAL MARKER EXPRESSING STEM CELLS AND THEIR COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASES (VERSIONS) | 2017 |
|
RU2742828C2 |
| METHOD OF TREATING NERVOUS SYSTEM INJURY USING RECOMBINANT GLUTAMATE OXALOACETATE TRANSAMINASE | 2018 |
|
RU2712193C1 |
