FIELD: biotechnology.
SUBSTANCE: following is described: a group of inventions including a nucleotide molecule for recombination design of DH-DH, a targeting vector, a method of modifying immunoglobulin heavy chain variable region to construct DH-DH recombination in an animal, immunoglobulin heavy chain nucleic acid to construct DH-DH recombination, rodent nucleic acid to construct DH-DH recombination, rodent cell for constructing recombination DH-DH, a rodent for constructing recombination DH-DH, a rodent embryo for constructing recombination DH-DH, a method of producing a rodent whose genome contains an engineered DH region (variants), a method of producing an antibody, and a method of obtaining a nucleic acid encoding an antibody.
EFFECT: invention expands the arsenal of tools for designing recombination DH-DH.
78 cl, 17 dwg, 7 tbl, 4 ex
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