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(19)

(11)

2 689 664

(13)

(51)

IPC

A01K67/27(2006-01-01)

C07K16/46(2006-01-01)

C12N15/85(2006-01-01)

(21) (22)

Application

2015143110, 2014-03-13

(24)

Start date

2014-03-13

(22)

Actual filing date

2014-03-13

(45)

Published

2019-05-28

(72)

Inventor

Babb RobertMcwhirter JohnMacdonald LynnStevens SeanDavis SamuelBuckler David R.Meagher Karolina A.Murphy Andrew J.

(73)

Holder

Regeneron Farmatyutikalz, Ink.

MICE EXPRESSING LIMITED IMMUNOGLOBULIN LIGHT CHAIN REPERTOIRE Russian patent published in 2019 - IPC A01K67/27 C07K16/46 C12N15/85

Abstract RU 2689664 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry, in particular to a genetically modified mouse for producing an antibody comprising in its germline genome two non-arranged gene segments Vκ human immunoglobulin and five non-arranged gene segments Jκ human immunoglobulin, functionally associated with mouse immunoglobulin light chain constant region sequence, as well as one or more non-aligned gene segments V_H human immunoglobulin, one or more non-arranged gene segments D_H human immunoglobulin and one or more non-arranged gene segments J_H human immunoglobulin, functionally associated with a mouse immunoglobulin heavy chain constant region sequence, as well as to use thereof for producing an antibody and for identifying a nucleic acid sequence encoding a human immunoglobulin heavy chain variable domain. Also disclosed is an isolated B-cell from said genetically modified mouse, as well as a hybridoma, obtained from said B-cell.

EFFECT: invention enables efficient antibody production.

15 cl, 19 dwg, 26 tbl, 14 ex

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RU 2 689 664 C2

Authors

Babb Robert

Mcwhirter John

Macdonald Lynn

Stevens Sean

Davis Samuel

Buckler David R.

Meagher Karolina A.

Murphy Andrew J.

Dates

2019-05-28—Published

2014-03-13—Filed