METHODS OF OBTAINING PNEUMOCOCCAL POLYSACCHARIDES COMPOSITIONS FOR CONJUGATION WITH CARRIER PROTEIN Russian patent published in 2023 - IPC A61K39/02 A61K39/85 A61K39/116 A61P11/00 A61P31/04

Abstract RU 2805605 C2

FIELD: pharmacology and immunology.

SUBSTANCE: invention relates to a method of lyophilization of a solution containing activated S. Pneumoniae polysaccharide. The following is disclosed: a method of lyophilizing a solution containing an activated S. Pneumoniae polysaccharide to obtain a lyophilized material, wherein the activated S. Pneumoniae polysaccharide is selected from the group consisting of polysaccharides from S. Pneumoniae serotypes 3, 8 and 24F, where the method includes the following: a) adding sugar, selected from sucrose or trehalose, or a combination of sucrose and trehalose, to a solution containing an activated S. pneumoniae polysaccharide to obtain a sugar:polysaccharide weight ratio of at least 40 and a solution of a suitable viscosity; and b) lyophilizing a solution of suitable viscosity containing the activated S. pneumoniae polysaccharide to obtain a lyophilized material, where the lyophilized material is suitable for redissolving in dimethyl sulfoxide (DMSO) and use in conjugation reactions.

EFFECT: invention improves the dissolution of the polysaccharide, which leads to effective conjugation.

2 cl, 3 dwg, 9 tbl, 7 ex

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RU 2 805 605 C2

Authors

Makkhyu, Patrik

Uinterz, Majkl Albert

Konietsko, Dzhenell

Dates

2023-10-20—Published

2018-09-04—Filed