PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-PROTEIN-CARRIER CONJUGATES Russian patent published in 2022 - IPC A61K31/35 A61K31/715 A61K39/85 C12P19/04 

FIELD: biochemistry; immunology.

SUBSTANCE: group of inventions relates to the field of biochemistry and immunology, namely to capsule polysaccharides of Streptococcus pneumoniae serotypes. A polysaccharide-protein-carrier conjugate is disclosed, in which polysaccharide has a repeating link of polysaccharide of S. pneumoniae of 23B serotype, and where a protein carrier is CRM197; and where the conjugate additionally has molecular weight from 1000 to 10,000 kDa. In addition, a polysaccharide-protein-carrier conjugate is described, in which polysaccharide has a repeating link of polysaccharide of S. pneumoniae of 23B serotype, and where a protein carrier is CRM197, and where the polysaccharide-protein-carrier conjugate additionally has a mass ratio of polysaccharide and the protein carrier from 0.5 to 3.0.

EFFECT: group of inventions provides high immunogenicity, which can be used in multivalent pneumococcal conjugated vaccines.

30 cl, 15 dwg, 2 tbl, 9 ex