PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN POLYSACCHARIDE-PROTEIN-CARRIER IMMUNOGENIC CONJUGATES Russian patent published in 2023 - IPC A61K31/715 A61K39/02 A61K47/64 A61P43/00 

FIELD: chemistry; pharmaceuticals.

SUBSTANCE: group of inventions relates to an immunogenic polysaccharide-carrier protein conjugate in which the polysaccharide contains a repeating unit of the following structure:

,

where x is a molar ratio of 0.0–1.0, wherein the carrier protein is CRM197, Diphtheria toxin fragment B (DTFB), DTFB C8, Diphtheria toxoid (DT), Tetanus toxoid (TT), TT fragment C, pertussis toxoid, cholera toxoid, E. coli LT, E. coli ST, or exotoxin A from Pseudomonas aeruginosa, and further wherein the polysaccharide-carrier protein conjugate has a mass ratio of polysaccharide to carrier protein of 0.5–2.0, and also refers to an immunogenic polysaccharide-carrier protein conjugate in which the polysaccharide contains a repeating unit of the following structure:

,

where x is a molar ratio from 0 to 1.0; where the carrier protein is CRM197; and further besides the polysaccharide-carrier protein conjugate has a molecular weight of 1,000–10,000 kDa.

EFFECT: group of inventions provides expansion of the arsenal of conjugates of bacterial capsular polysaccharides and immunogenic compositions based on them.

29 cl, 17 dwg, 2 tbl, 9 ex