METHOD OF DIFFERENTIAL DIAGNOSTICS OF CORNEAL CHANGES IN FUCHS ENDOTHELIAL DYSTROPHY IN BULL STAGE AND BULLOUS KERATOPATHY CAUSED BY DAMAGE TO ENDOTHELIAL LAYER Russian patent published in 2023 - IPC A61B3/117 

FIELD: ophthalmology.

SUBSTANCE: invention is intended for the differential diagnosis of Fuchs endothelial dystrophy (ED) in the bullous stage and bullous keratopathy (BC). Optical coherence tomography of the cornea is performed in the automatic scan averaging mode. The vertical size of the DM, the presence of uneven thickenings of the posterior hyperreflective line of the DM and the slit-like space between the DM and the stroma, the vertical size of the stroma, the optical density of the stroma, the presence of microcysts and epithelial bullae are determined. With a vertical size of the DM equal to 17 μm or more, uneven thickening of the posterior hyperreflective line of the DM, the presence of a slit-like space between the DM and the stroma, uneven optical density of the stroma in the form of hyporeflective lacunae, vertical hyporeflective striae and hyperreflective zones of densely located fibers, vertical size of the stroma in the projection of bullae more than 600 microns, and the presence of microcysts and epithelial bullae, Fuchs' ED is diagnosed. With the vertical size of the DM less than 16 µm, a uniform profile of the posterior hyperreflective line of the DM, the absence of a slit-like space between the DM and the stroma, uneven optical density of the stroma in the form of hyporeflective lacunae, vertical hyporeflective striae and hyperreflective zones of densely located fibers, the vertical size of the stroma in the projection of bullae more than 600 µm and the presence of microcysts and epithelial bullae, BC caused by damage to the endothelial layer is diagnosed.

EFFECT: invention provides the possibility of choosing a pathogenetically oriented treatment method depending on the type of corneal pathology due to the stated diagnostic criteria.

1 cl, 3 ex