COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS Russian patent published in 2020 - IPC C07J7/00 C07J43/00 A61K31/57 A61K31/58 A61P25/08 A61P25/18 A61P25/20 A61P25/28 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I-a), in which ring A is 5-member or 9-member heteroaryl containing 2–4 nitrogen atoms; where ring A is attached through a nitrogen atom; R¹ denotes unsubstituted C_1-3 alkyl or alkoxyC_1-6alkyl; R² is hydrogen; R^3a is hydrogen and R^3b is hydrogen; R^4a is hydrogen; R⁶ is unsubstituted C_1-6alkyl, hydroxyC_1-6alkyl, haloC_1-6alkyl, halogen, cyano, nitro, OR^A6, C(=O)OR^A6, N(R^C6)(R^D6), C(=O)N(R^C6)(R^D6) or N(R^C6)C(=O)R^A6; n has value 1; R^A6 represents hydrogen or unsubstituted C_1-6alkyl and each of R^C6 and R^D6 independently represents hydrogen or unsubstituted C_1-6alkyl; R⁵ denotes hydrogen; each of R^7a and R^7b independently represents hydrogen and represents a simple bond. Invention also relates to individual compounds, a pharmaceutical composition, a method of treating convulsions, a method of treating epilepsy, a method of treating a CNS-related disorder.

(I-a).

EFFECT: obtaining novel compounds of formula (I-a), having properties of GABA modulators.

38 cl, 3 tbl, 161 ex