METHOD OF DIFFERENTIAL DIAGNOSTICS OF ORAL CAVITY DYSBIOSIS IN PATIENTS WITH CHRONIC BILIARY-DEPENDENT PANCREATITIS WITH DIFFERENT EXECRETORY ACTIVITY Russian patent published in 2023 - IPC G01N33/50 G01N33/52 G01N33/84 A61B5/00 

FIELD: medicine; therapeutic dentistry; laboratory diagnostics.

SUBSTANCE: invention can be used for a differentiated approach to the diagnostics of oral dysbiosis. In the oral fluid, urease activity, ammonia concentration, pH level, and light sum of luminescence during chemiluminescence are determined; in oral smears, the concentrations of urease-positive and opportunistic microbiota are determined. With a urease activity value of 0.663μ mole⋅min^-1 per mg of protein, ammonia level 0.089 mmol, pH 5.3, luminescence sum 20.3 u/e, urease-positive Staphylococcus spp. and Enterobacteriaceae spp. in an amount of 10⁴ CFU/unit, gram-positive facultative anaerobic rods Lactobacillus spp. in an amount of 10⁴ CFU/unit and opportunistic yeast-like fungi of the genus Candida in yeast form in an amount of 10^3-4 CFU/unit oral dysbiosis is diagnosed against the background of chronic biliary-dependent pancreatitis. With a urease activity value of 0.778μ mole⋅min^-1 per mg of protein, ammonia level 0.031 mmol, pH 5.6, luminescence sum 22.5 u/e, urease-positive Staphylococcus spp. and Enterobacteriaceae spp. in an amount of 10⁵ CFU/unit, gram-positive facultative anaerobic rods Lactobacillus spp. in an amount of 10⁵ CFU/unit and opportunistic yeast-like fungi of the genus Candida in mycelial form in an amount of 10^4-5 CFU/unit oral dysbiosis is diagnosed against the background of chronic biliary-dependent pancreatitis with symptoms of gastroesophageal reflux disease.

EFFECT: use of the invention improves prediction accuracy.

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