METHOD FOR DIFFERENTIAL DIAGNOSIS OF ORAL DYSBIOSIS IN PATIENTS WITH CROHN'S DISEASE OR ULCERATIVE COLITIS Russian patent published in 2024 - IPC G01N33/48 G01N33/50 G01N21/80 A61B5/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to therapeutic dentistry and laboratory diagnostics, and can be used for differential approach to diagnosis of oral dysbiosis in patients with Crohn's disease (CD) or ulcerative colitis (UC). Level of pH and free-radical oxidation state are determined in oral fluid, presence of gram-positive and gram-negative facultative anaerobes, gram-positive and gram-negative anaerobes and yeast fungi of the genus Candida is determined in the oral microbiota. At pH values of 4.7, light sum of luminescence is 10.85 c.u., amount of Staphylococcus spp. 10⁵ CFU/unit, Enterococcus spp. 10² CFU/unit, Lactobacillus spp. 10⁵ CFU/unit, Bifidobacterium spp. 10⁵ CFU/unit, Enterobacteriaceae spp. 10⁵ CFU/unit, Fusobacteria spp. 10⁵ CFU/unit, and yeast fungi of the genus Candida in mycelial form in amount of 10^4-5 CFU/unit, oral dysbiosis with underlying CD is diagnosed. At pH values of 4.9, light sum of luminescence is 9.76 c.u., amount of Staphylococcus spp. 10⁴ CFU/unit, Enterococcus spp. 10² CFU/unit, Lactobacillus spp. 10⁴ CFU/unit, Bifidobacterium spp. 10⁶ CFU/unit, Enterobacteriaceae spp. 10⁴ CFU/unit, Fusobacteria spp. 10⁴ CFU/unit, and yeast fungi of the genus Candida in yeast form in amount of 10^3-4 CFU/unit, oral dysbiosis with underlying UC is diagnosed.

EFFECT: use of the invention improves accuracy of differential diagnosis.

1 cl, 1 tbl, 2 ex