AMINOBORNANE DERIVATIVE AND METHOD OF ITS OBTAINING, AS WELL AS ITS USE Russian patent published in 2023 - IPC C07D487/04 A61K31/5377 A61P37/02 A61P35/00 A61P29/00 A61P11/06 A61P35/02 

FIELD: organic chemistry; pharmaceuticals.

SUBSTANCE: group of inventions relates to an aminonorbornane derivative as an inhibitor of Bruton's tyrosine kinase with high selectivity towards the BTK(C481S) mutant. The following is disclosed: a compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein Ring A, Ring B, Ring C and wherein the values of L, R¹, R² and R⁵ are as set forth in the claims. In addition, a specific compound selected from the group, the use of the above compounds in the production of a medicinal product, pharmaceutical compositions and compositions for preventing the development or treatment of a heteroimmune disease based on these compounds are disclosed. A method of preparing the presented compounds is also disclosed.

EFFECT: group of inventions provides effective inhibition of Bruton's tyrosine kinase with high selectivity towards the BTK(C481S) mutant, which provides treatment for a heteroimmune disease, autoimmune disease or cancer.

22 cl, 2 dwg, 4 tbl, 6 ex