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2 809 444

(13)

(51)

IPC

G01N33/50(2006-01-01)

C12Q1/6806(2018-01-01)

C12Q1/6827(2018-01-01)

C12Q1/686(2018-01-01)

C12Q1/6876(2018-01-01)

C12Q1/6883(2018-01-01)

(21) (22)

Application

2023117826, 2023-07-06

(24)

Start date

2023-07-06

(22)

Actual filing date

2023-07-06

(45)

Published

2023-12-11

(72)

Inventor

Azarova Iuliia EduardovnaAzarova Valentina AlekseevnaKorviakova Iaroslava EvgenevnaKlesova Elena IurevnaPolonikov Aleksei Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD OF PREDICTING RISK OF DEVELOPING CHRONIC HEART FAILURE IN MEN WITH TYPE 2 DIABETES MELLITUS BASED ON GENOTYPING OF rs4932143 POLYMORPHISM OF ANPEP GENE Russian patent published in 2023 - IPC G01N33/50 C12Q1/6806 C12Q1/6827 C12Q1/686 C12Q1/6876 C12Q1/6883

Abstract RU 2809444 C1

FIELD: medicine; medical diagnostics.

SUBSTANCE: invention can be used to predict the risk of developing chronic heart failure in men with type 2 diabetes. A sample of peripheral venous blood is taken and DNA is extracted. Analysis of the polymorphic variant of the aminopeptidase gene ANPEP rs4932143 (A>C) is carried out. If genotypes C/G or G/G are detected, an increased risk of developing chronic heart failure is predicted. If the C/C genotype is detected, a low risk is predicted.

EFFECT: method provides new criteria for assessing the risk of developing chronic heart failure in men in Central Russia with type 2 diabetes mellitus based on data on the genetic polymorphism rs4932143 (C>G) of the ANPEP gene.

1 cl, 1 dwg, 1 tbl, 3 ex

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RU 2 809 444 C1

Authors

Azarova Iuliia Eduardovna

Azarova Valentina Alekseevna

Korviakova Iaroslava Evgenevna

Klesova Elena Iurevna

Polonikov Aleksei Valerevich

Dates

2023-12-11—Published

2023-07-06—Filed