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2 837 003

(13)

(51)

IPC

G01N33/49(2006-01-01)

G01N27/62(2006-01-01)

C12Q1/6804(2018-01-01)

C12Q1/6872(2018-01-01)

(21) (22)

Application

2024130452, 2024-10-09

(24)

Start date

2024-10-09

(22)

Actual filing date

2024-10-09

(45)

Published

2025-03-25

(72)

Inventor

Korviakova Iaroslava EvgenevnaAzarova Iuliia EduardovnaKlesova Elena IurevnaPolonikov Aleksei Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR PREDICTION OF RISK OF DEVELOPING CARDIOVASCULAR AUTONOMOUS NEUROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS BASED ON GENOTYPING OF POLYMORPHISM rs8041622 (G>A) OF ANPEP GENE Russian patent published in 2025 - IPC G01N33/49 G01N27/62 C12Q1/6804 C12Q1/6872

Abstract RU 2837003 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to clinical laboratory diagnostics, and can be used to predict the risk of developing cardiovascular autonomous neuropathy in patients with type 2 diabetes mellitus. A sample of peripheral venous blood is taken. DNA extraction is followed by analysis of polymorphic variant rs8041622 (G>A) of the ANPEP gene. In case detection of genotype rs8041622-A/A, high risk of developing cardiovascular autonomous neuropathy is predicted. In case detection of genotype rs8041622-G/G or rs8041622-G/A, low risk of developing cardiovascular autonomous neuropathy is predicted.

EFFECT: method provides obtaining new criteria for assessing the risk of developing cardiovascular autonomous neuropathy in patients with type 2 diabetes mellitus based on genotyping polymorphism rs8041622 (G>A) of the ANPEP gene.

1 cl, 1 tbl, 3 ex

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RU 2 837 003 C1

Authors

Korviakova Iaroslava Evgenevna

Azarova Iuliia Eduardovna

Klesova Elena Iurevna

Polonikov Aleksei Valerevich

Dates

2025-03-25—Published

2024-10-09—Filed