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2 828 572

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(51)

IPC

G01N33/52(2006-01-01)

G01N33/49(2006-01-01)

C12Q1/6804(2018-01-01)

C12Q1/6827(2018-01-01)

C12Q1/6876(2018-01-01)

C12Q1/6883(2018-01-01)

(21) (22)

Application

2024110095, 2024-04-13

(24)

Start date

2024-04-13

(22)

Actual filing date

2024-04-13

(45)

Published

2024-10-14

(72)

Inventor

Petrukhina Irina IurevnaKlesova Elena IurevnaAzarova Iuliia EduardovnaIlina Elizaveta AndreevnaPolonikov Aleksei Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR PREDICTING RISK OF DEVELOPING DIABETIC DISTAL POLYNEUROPATHY IN PEOPLE OF CENTRAL RUSSIA WITH TYPE 2 DIABETES MELLITUS BASED ON GENOTYPING OF HSF1 GENE rs12542298 POLYMORPHISM Russian patent published in 2024 - IPC G01N33/52 G01N33/49 C12Q1/6804 C12Q1/6827 C12Q1/6876 C12Q1/6883

Abstract RU 2828572 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to medical diagnostics, and can be used for prediction of risk of developing diabetic distal polyneuropathy in people of Central Russia with type 2 diabetes mellitus. A sample of peripheral venous blood is taken. DNA extraction is followed by analysis of polymorphic variant rs12542298 (T>C) of the HSF1 gene of family of heat shock proteins. If the genotype rs12542298-C/C is detected, an increased risk of diabetic distal polyneuropathy is predicted. If observing the genotype rs12542298-T/C or rs12542298-T/T, a low risk of developing diabetic distal polyneuropathy is predicted.

EFFECT: method provides obtaining new criteria for assessing the risk of developing diabetic distal polyneuropathy in people of Central Russia with type 2 diabetes mellitus according to the genetic polymorphism rs12542298 (T>C).

1 cl, 1 tbl, 3 ex

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RU 2 828 572 C1

Authors

Petrukhina Irina Iurevna

Klesova Elena Iurevna

Azarova Iuliia Eduardovna

Ilina Elizaveta Andreevna

Polonikov Aleksei Valerevich

Dates

2024-10-14—Published

2024-04-13—Filed