METHOD OF PREDICTING RISK OF DEVELOPING DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND NORMAL BODY WEIGHT BASED ON GENOTYPING OF rs9920421 AND rs4932143 POLYMORPHISMS OF ANPEP GENE Russian patent published in 2023 - IPC G01N33/52 G01N33/49 C12Q1/6804 C12Q1/6827 C12Q1/6876 C12Q1/6883 

Abstract RU 2809443 C1

FIELD: medicine; medical diagnostics.

SUBSTANCE: invention can be used to predict the risk of developing diabetic nephropathy in patients with type 2 diabetes mellitus and normal body weight. A sample of peripheral venous blood is taken and DNA is extracted. An analysis of polymorphic variants of the aminopetidase gene ANPEP rs9920421 (A>G) and rs4932143 (C>G) is carried out. If a combination of the G allele rs9920421 with the G allele rs4932143 is detected, an increased risk of diabetic nephropathy is predicted. If a combination of the A allele of rs9920421 with the C allele of rs4932143 is detected, a low risk is predicted.

EFFECT: method provides new criteria for assessing the risk of diabetic nephropathy in patients of Central Russia with type 2 diabetes mellitus and normal body weight based on data on genetic polymorphisms rs9920421 (A>G) and rs4932143 (C>G).

1 cl, 2 dwg, 1 tbl, 3 ex

Similar patents RU2809443C1

Title Year Author Number
METHOD OF PREDICTING RISK OF DEVELOPING CHRONIC HEART FAILURE IN MEN WITH TYPE 2 DIABETES MELLITUS BASED ON GENOTYPING OF rs4932143 POLYMORPHISM OF ANPEP GENE 2023
  • Azarova Iuliia Eduardovna
  • Azarova Valentina Alekseevna
  • Korviakova Iaroslava Evgenevna
  • Klesova Elena Iurevna
  • Polonikov Aleksei Valerevich
RU2809444C1
METHOD FOR PREDICTING THE RISK OF DEVELOPING TYPE 2 DIABETES IN RESIDENTS OF CENTRAL RUSSIA BASED ON GENOTYPING OF THE rs11073891 POLYMORPHISM OF THE ANPEP GENE 2023
  • Azarova Iuliia Eduardovna
  • Klesova Elena Iurevna
  • Polonikov Aleksei Valerevich
  • Korviakova Iaroslava Evgenevna
RU2803636C1
METHOD OF PREDICTING RISK OF DEVELOPING DIABETIC DISTAL POLYNEUROPATHY IN RESIDENTS OF CENTRAL RUSSIA WITH TYPE 2 DIABETES MELLITUS BASED ON GENOTYPING OF rs1043618 POLYMORPHISM OF HSPA1A GENE 2023
  • Klesova Elena Iurevna
  • Azarova Iuliia Eduardovna
  • Ilina Elizaveta Andreevna
  • Polonikov Aleksei Valerevich
RU2809905C1
METHOD OF PREDICTING RISK OF DEVELOPING DIABETIC FOOT SYNDROME IN RESIDENTS OF CENTRAL RUSSIA WITH TYPE 2 DIABETES MELLITUS BASED ON GENOTYPING OF RS7517862 POLYMORPHISM OF ATF6 GENE 2023
  • Petrukhina Irina Iurevna
  • Klesova Elena Iurevna
  • Azarova Iuliia Eduardovna
  • Ilina Elizaveta Andreevna
  • Polonikov Aleksei Valerevich
RU2811753C1
METHOD FOR PREDICTING THE RISK OF DEVELOPING DIABETIC RETINOPATHY IN MEN WITH TYPE 2 DIABETES MELLITUS BASED ON RS836478 POLYMORPHISM GENOTYPING IN THE RAC1 GENE 2022
  • Azarova Iuliia Eduardovna
  • Klesova Elena Iurevna
  • Polonikov Aleksei Valerevich
RU2786820C1
METHOD FOR PREDICTING THE RISK OF DEVELOPING DIABETIC DISTAL POLYNEUROPATHY IN WOMEN WITH TYPE 2 DIABETES MELLITUS BASED ON RS7784465 GENOTYPING OF THE RAC1 GENE POLYMORPHISM RS7784465 2022
  • Azarova Iuliia Eduardovna
  • Klesova Elena Iurevna
  • Polonikov Aleksei Valerevich
RU2787273C1
METHOD FOR PREDICTING THE RISK OF DEVELOPING TYPE 2 DIABETES IN RESIDENTS OF CENTRAL RUSSIA BASED ON GENOTYPING OF THE rs755892 POLYMORPHISM OF THE DNAJB1 GENE 2023
  • Klesova Elena Iurevna
  • Azarova Iuliia Eduardovna
  • Polonikov Aleksei Valerevich
RU2803637C1
METHOD FOR PREDICTING THE RISK OF DEVELOPING ISCHEMIC HEART DISEASE IN MEN WITH TYPE 2 DIABETES MELLITUS BASED ON GENOTYPING POLYMORPHISM rs16931366 OF ITPR2 GENE 2024
  • Azarova Iuliia Eduardovna
  • Postnikova Mariia Igorevna
  • Azarova Valentina Alekseevna
  • Klesova Elena Iurevna
  • Mikhin Vadim Petrovich
  • Polonikov Aleksei Valerevich
RU2821764C1
METHOD FOR PREDICTION OF CLINICAL COURSE AND TREATMENT EFFICACY OF TYPE 2 DIABETES MELLITUS 2013
  • Churnosov Mikhail Ivanovich
  • Belousova Oksana Nikolaevna
  • Sirotina Svetlana Sergeevna
  • Churnosova Julija Jur'Evna
  • Polonikov Aleksej Valer'Evich
RU2533286C1
METHOD FOR EARLY PREDICTION OF THE RISK OF DEVELOPMENT OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE 1 DIABETES MELLITUS 2022
  • Kostyushok Nadezhda Yanovna
  • Ivanova Lyudmila Aleksandrovna
  • Pavlyuchenko Ivan Ivanovich
RU2793531C1

RU 2 809 443 C1

Authors

Azarova Iuliia Eduardovna

Azarova Valentina Alekseevna

Korviakova Iaroslava Evgenevna

Klesova Elena Iurevna

Polonikov Aleksei Valerevich

Dates

2023-12-11Published

2023-07-06Filed