FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, particularly oncology, and may be applied in treating cancer. A method involves producing stem CD8+T-cells from a subject, introducing cladribine into the subject; contacting the CD8+ T-cells with xenogenic antigen-representing cells loaded with one or more peptide antigens with generating thereby the activated cytotoxic T-lymphocytes (CTL) which are targeted on the cells expressing said one or more peptide antigens. Then the activated CTLs and at least two cytokines which have an effect on CTL persistence are introduced into the subject.
EFFECT: use of the invention provides higher clinical effectiveness ensured by prolonged persistence of the activated CTLs and reduced number of complications, namely opportunistic infections.
10 cl, 1 tbl, 2 dwg, 1 ex
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