COMPOSITIONS AND METHODS OF IMPROVING LIBRARY ENRICHMENT Russian patent published in 2023 - IPC C12Q1/6832 

Abstract RU 2809771 C2

FIELD: biotechnology.

SUBSTANCE: following is provided: a hybridization buffer that includes dextran sulfate, human Cot-1 DNA, formamide, KH2PO4-K2HPO4, NaCl, TWEEN 20, and improved adapter blockers. The invention also relates to a method and a set for obtaining an enriched library containing a collection of nucleic acid members.

EFFECT: invention provides improved efficiency of nucleic acid selection before sequencing.

9 cl, 31 dwg, 11 tbl, 9 ex

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RU 2 809 771 C2

Authors

Slatter, Andrew F.

Zhao, Junhua

Desantis, Grace

Gross, Stephen M.

Hogan, Hayley M.

Li, Jian-Sen

Miller, Oliver J.

Dates

2023-12-18Published

2019-08-13Filed