FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and molecular biology, particularly to methods of producing a sequencing library comprising nucleic acids from a plurality of single cells. Methods of the present invention relate to production of combinatorial indexed libraries for sequencing single cells and obtaining sequence data therefrom.
EFFECT: in some embodiments, the sequence data obtained from the libraries are exhaustive, and in other embodiments, the sequence data obtained from the libraries enables to characterize rare events.
59 cl, 11 dwg, 6 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HIGH-PERFORMANCE LIBRARIES OF SINGLE NUCLEI AND SINGLE CELLS AND METHODS FOR THEIR PRODUCTION AND USE | 2020 |
|
RU2838545C2 |
| LARGE-SCALE MONOCELLULAR TRANSCRIPTOME LIBRARIES AND METHODS FOR THEIR PRODUCTION AND USE | 2019 |
|
RU2773318C2 |
| HIGH-PERFORMANCE SINGLE CELL SEQUENCING WITH REDUCED AMPLIFICATION ERROR | 2019 |
|
RU2744175C1 |
| HIGH-THROUGHPUT SINGLE CELL SEQUENCING WITH REDUCED AMPLIFICATION ERROR | 2019 |
|
RU2833615C2 |
| GENOME-WIDE LIBRARIES OF INDIVIDUAL CELLS FOR BISULFITE SEQUENCING | 2018 |
|
RU2770879C2 |
| ANALYSIS SYSTEM FOR ORTHOGONAL ACCESS TO BIOMOLECULES AND THEIR LABELLING IN CELL COMPARTMENTS | 2017 |
|
RU2771892C2 |
| ANALYSIS OF MULTIPLE ANALYTES USING ONE ANALYSIS | 2019 |
|
RU2824049C2 |
| METHODS FOR ENCAPSULATING SINGLE CELLS, ENCAPSULATED CELLS, AND METHODS OF APPLICATION THEREOF | 2019 |
|
RU2750567C2 |
| METHODS OF ENCAPSULATING SINGLE CELLS, THE ENCAPSULATED CELLS AND USES THEREOF | 2019 |
|
RU2793717C2 |
| METHODS AND MEANS OF PRODUCING SEQUENCING LIBRARY | 2019 |
|
RU2815513C2 |
