METHOD OF PREDICTING OUTCOME OF ADVANCED CUTANEOUS MELANOMA DURING THERAPY WITH CHECKPOINT INHIBITORS Russian patent published in 2023 - IPC G01N33/48 A61B5/00 A61P35/00 

FIELD: medicine; chemotherapy.

SUBSTANCE: invention can be used to predict the outcome of advanced skin melanoma during therapy with checkpoint inhibitors. The method includes the following: a blood test, determining the risk of progression of skin melanoma, where at the outpatient stage, before prescribing anti-PD-1 therapy, the relative, percentage number of lymphocytes DN, T-reg, CD8+HLADR, CD4+HLADR, CD8+CD95+ and NK is determined by flow cytometry. Then a clinical assessment of the prevalence of the disease is carried out, and the individual risk of progression of skin melanoma (Y) is calculated using the formula. If the LR value is more than 0.25, an unfavorable course of the disease is predicted.

EFFECT: invention makes it possible to assess the prognosis of the disease already at the outpatient stage by determining indicators of immune status in addition to standard criteria, such as the extent of the tumor process and tumor thickness.

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