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RU

(11)

2 810 843

(13)

C1

(51)

IPC

A61K31/55(2006-01-01)

A61P9/00(2006-01-01)

(21) (22)

Application

2022127989, 2022-10-28

(24)

Start date

2022-10-28

(22)

Actual filing date

2022-10-28

(45)

Published

2023-12-28

(72)

Inventor

Malashicheva Anna BorisovnaBoiarskaia Nadezhda VladimirovnaLobov Arsenii AndreevichUspenskii Vladimir EvgenevichKachanova Olga SergeevnaShishkova Anastasiia AlekseevnaPishchugin Aleksandr SergeevichFilippov Aleksei Aleksandrovich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Meditsinskii Issledovatelskii Tsentr Imeni V.A. Almazova" Ministerstva Zdravookhraneniia Rossiiskoi

AGENT FOR SUPPRESSING OSTEOGENIC DIFFERENTIATION OF HUMAN HEART VALVE INTERSTITIAL CELLS Russian patent published in 2023 - IPC A61K31/55 A61P9/00 

Abstract RU 2810843 C1

FIELD: medicine.

SUBSTANCE: invention relates to the means for the treatment of diseases of cardiovascular system. The use of a medicinal product containing crenigacestat as an active substance in a concentration of 50–100 nM to suppress osteogenic differentiation of interstitial cells of the human heart valve is disclosed.

EFFECT: invention provides high selectivity and anti-calcification effect in a non-toxic dosage.

1 cl, 3 dwg, 3 ex

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RU 2 810 843 C1

Authors

Malashicheva Anna Borisovna

Boiarskaia Nadezhda Vladimirovna

Lobov Arsenii Andreevich

Uspenskii Vladimir Evgenevich

Kachanova Olga Sergeevna

Shishkova Anastasiia Alekseevna

Pishchugin Aleksandr Sergeevich

Filippov Aleksei Aleksandrovich

Dates

2023-12-28—Published

2022-10-28—Filed

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