ANALOGUE OF INDOLOHEPTAMILOXIME AS A PARP INHIBITOR Russian patent published in 2024 - IPC C07D498/06 A61K31/553 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to a new type of indoleheptamyloxime compounds as a PARP inhibitor. The following is disclosed: a compound of formula (II), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof,

,

where selected from the group consisting of a single bond and a double bond; X is selected from the group consisting of CR ₃ and N; Y is selected from the group consisting of CR₁ and C; L₁ is selected from the group consisting of a single bond and -(CR₈R₉)_n; L₂ is selected from the group consisting of a single bond, -CR₈R₉- and =CH-; L₁ and L₂ do not represent single bonds at the same time; if L₂ is selected from a single bond, then selected from a single bond; each of L₃ and L₄ is independently selected from -CR₈R₉-; n is either 1 or 2; R₁ is selected from the group consisting of H, D, F, Cl, Br, I and C_1-3 alkyl, and if L₂ is selected from =CH-, then R₁ is absent; each of R₂ and R₁₀ is independently selected from the group consisting of H, F, Cl, Br and I; R₃ is selected from the group consisting of H, F, Cl, Br and I; R₄ is selected from the group consisting of H and F; R₅ is selected from the group consisting of H and C_1-3 alkyl; each of R₆ and R₇ is independently selected from the group consisting of H and D; each of R₈ and R₉ is H. Also the following is disclosed: compounds falling under formula (II), a pharmaceutical composition containing a compound of formula (II), a method of treating a PARP receptor-associated disease using a compound of formula (II), and the use of compounds of formula (II) for the treatment of a disease associated with the PARP receptor.

EFFECT: provision of indolheptamyloxime compounds as a PARP inhibitor.

24 cl, 10 tbl, 89 ex