COMPOSITIONS OF GRAPIPRANTE AND METHODS OF THEIR USE Russian patent published in 2024 - IPC A61K31/437 A61K31/64 A61P29/00 C07D487/04 

FIELD: veterinary medicine.

SUBSTANCE: invention discloses a method of treating pain or inflammation in a dog or cat in need thereof, comprising administering to the dog or a cat a pharmaceutical composition containing a therapeutically effective amount of grapiprant, a surfactant and at least one excipient, wherein the therapeutically effective amount of grapiprant administered orally at a dose rate of 2 to 4 mg per kilogram of a dog or cat body weight at least once daily; wherein the surfactant is selected from poloxamer or sodium lauryl sulfate and is present in an amount of from 0.1% to 5% by weight of the total weight of the composition, wherein at least one excipient includes one or more selected from the group consisting of lactose, sodium starch glycolate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate and copovidone.

EFFECT: claimed invention provides high efficiency in the treatment of pain or inflammation in a dog or cat when using low doses of grapiprant.

14 cl, 20 dwg, 19 tbl, 15 ex