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2 811 995

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IPC

C12Q1/68(2006-01-01)

C12Q1/6844(2018-01-01)

C12Q1/686(2018-01-01)

C12Q1/6876(2018-01-01)

(21) (22)

Application

2023121770, 2023-08-18

(24)

Start date

2023-08-18

(22)

Actual filing date

2023-08-18

(45)

Published

2024-01-22

(72)

Inventor

Doronin Maksim IgorevichMalygin Maksim PavlovichMikhalishin Dmitrij ValerevichChvala Ilya AleksandrovichBorisov Aleksej ValerevichRazgulyaeva Evgeniya AleksandrovnaGochmuradov Ykhlas Muradovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Tsentr Okhrany Zdorovya Zhivotnykh"

METHOD OF INDIRECT DETERMINING TITER OF INFECTIOUS ACTIVITY OF RABIES VIRUS IN RAW MATERIALS FOR PRODUCTION OF ATTENUATED RABIES VACCINE USING TECHNOLOGY OF ALGEBRAIC ANALYSIS OF SECOND-ORDER DIFFERENTIAL OF MAXIMUM POINT d CPmax OF PCR LOGISTIC CURVE Russian patent published in 2024 - IPC C12Q1/68 C12Q1/6844 C12Q1/686 C12Q1/6876

Abstract RU 2811995 C1

FIELD: biotechnology.

SUBSTANCE: following is described: a method of indirect determining the titer of infectious activity of the rabies virus in raw materials for the production of attenuated rabies vaccine using the technology of algebraic analysis of the second-order differential of the maximum point d CP_max of the PCR logistic curve using developed original highly specific oligonucleotides.

EFFECT: development of a highly sensitive, highly specific, objective and fast-to-execute method of indirect determining the titer of infectious activity of the rabies virus in raw materials for the production of attenuated rabies vaccine, using the technology of algebraic analysis of the second-order differential of the maximum point d CP_max of the PCR logistic curve.

3 cl, 3 dwg, 5 tbl, 4 ex

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RU 2 811 995 C1

Authors

Doronin Maksim Igorevich

Malygin Maksim Pavlovich

Mikhalishin Dmitrij Valerevich

Chvala Ilya Aleksandrovich

Borisov Aleksej Valerevich

Razgulyaeva Evgeniya Aleksandrovna

Gochmuradov Ykhlas Muradovich

Dates

2024-01-22—Published

2023-08-18—Filed