METHOD OF PREDICTING ADVERSE OUTCOMES OF SEVERE FORMS OF CORONAVIRUS INFECTION IN PREGNANT WOMEN Russian patent published in 2024 - IPC G01N33/49 G01N33/68 G01N33/72 G01N33/74 G01N33/84 

FIELD: medicine; intensive care.

SUBSTANCE: invention can be used to predict the unfavorable outcome of severe forms of coronavirus infection in pregnant women. The following biochemical parameters in the blood are determined: leukocytes, bilirubin, LDH, IL-6, procalcitonin, pH. These indicators are taken into account as the difference in the indicator on the 3rd day and during hospitalization in the intensive care unit. The PI forecast is calculated using the following formula: PI=0.101+0.015*Leukocytes–0.024*Bilirubin+0.001*LDH+0.001*IL-6–0.004*Procalcitonin–0.027*pH, where Leukocytes is the difference in leukocytosis levels on the 3rd and 1st days, *10⁹/l; Bilirubin – difference in bilirubinemia on days 3 and 1, mcmol/l; LDH – difference in LDH levels on days 3 and 1, U/l; IL-6 – difference in IL-6 levels on days 3 and 1, pg/ml; Procalcitonin – difference in procalcitonin levels on days 3 and 1, mg/ml; pH – difference in pH level on the 3rd and 1st days. If the PI value is more than or equal to 0.3139, the prognosis is unfavorable; if it is less than 0.3139, the prognosis is favorable.

EFFECT: method provides the ability to identify a group of patients with an unfavorable course of COVID-19 and strengthen control over the patients' condition by determining a number of biochemical indicators in the blood and using an equation to assess the prognosis, where the differences in these indicators during hospitalization in the ICU (intensive care unit) and the 3rd day of treatment are used as variables.

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