FIELD: biotechnology.
SUBSTANCE: invention relates to methods, pharmaceutical compositions and sets for treating or mitigating the effects of a cancer in an individual that has an atypical BRAF mutation (i.e., a BRAF non-V600E/K mutation) comprising an ERK inhibitor. Also the methods of identifying an individual having a cancer with an atypical BRAF mutation who would benefit from a therapy comprising an ERK inhibitor are provided.
EFFECT: obtaining compositions and methods of treatment of cancer with BRAF atypical mutations.
68 cl, 4 dwg, 3 tbl, 1 ex
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