METHOD OF AETIOLOGICAL VERIFICATION OF CYTOMEGALOVIRUS ENCEPHALITIS IN PATIENTS WITH HIV INFECTION Russian patent published in 2024 - IPC G01N33/53 C12Q1/68 C12Q1/6851 

FIELD: biotechnology.

SUBSTANCE: method of the etiological verification of cytomegalovirus encephalitis in patients with HIV infection is described, the said method includes quantitative determination of human cytomegalovirus (HCMV) DNA in a sample of the patient’s biological material, in which the magnitude of CMV replicative activity in the CSF sample is determined in a patient with damage to the central nervous system of unknown aetiology.

EFFECT: invention expands the range of methods with increased diagnostic accuracy and establishment of clinically significant threshold concentrations of CMV DNA in biological samples of the examined patient, which makes it possible to fundamentally speed up the diagnostics of CNS lesions in HIV-infected patients with neurological pathology of unknown aetiology and, with a high degree of certainty, exclude the presence of CMV encephalitis by making conclusion about another cause of the central nervous system disease, or confirm the development of CMV encephalitis.

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