FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a new method of producing (E)-2-(7-trifluoromethylchroman-4-ylidene)-N-((7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalene-1-yl)acetamide, represented by Formula (I), which is a heterocyclidene acetamide derivative. The method includes carrying out a condensation reaction of a compound represented by Formula (B), or a salt thereof, and a compound represented by Formula (CA-1), using DMT-MM as a condensing reagent, obtaining a compound represented by Formula (I)
Formula (I):
[C118]
Formula (B):
[C119]
Formula (CA-1):
[C120]
EFFECT: new method of more easily obtaining the compound represented by formula (I) with high yield.
1 cl, 3 dwg, 30 tbl, 12 ex
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