FIELD: chemistry.
SUBSTANCE: group of inventions relates to organic chemistry and includes a compound of formula I, 2-((3-butyl-3-ethyl-7-(methylthio)-1,1-dioxide-5-phenyl-2,3,4,5-tetrahydrobenzo-1,2,5-thiadiazepin-8-yl)oxy) acetic acid, pharmaceutically acceptable salts thereof, a pharmaceutical composition and use of the compounds. In formula (I) R1 and R2 each independently represents C1-4alkyl; R3 is hydrogen; R4 is selected from the group consisting of C3-6cycloalkyloxy and C3-6cycloalkylthio.
EFFECT: technical result is 1,2,5-thiadiazepine derivatives possessing activity of inhibition of apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transporter (LBAT).
11 cl, 8 tbl, 3 ex
(I)
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