NEW DRUGS WITH CYTOTOXIC ACTIVITY BASED ON AZOLOAZINE DERIVATIVES FOR BREAST CANCER CHEMOTHERAPY Russian patent published in 2024 - IPC A61K31/53 A61K31/21 A61K31/167 A61K31/4188 A61P35/00 

FIELD: pharmaceutics; medicine.

SUBSTANCE: group of inventions relates to an agent with cytotoxic activity for breast cancer chemotherapy and to use of said agent for breast cancer chemotherapy. An agent with cytotoxic activity for breast cancer chemotherapy includes an active substance or a pharmaceutically acceptable salt thereof or a pharmaceutical composition based on an active substance or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable carriers and additives, according to the invention, it contains an azolotriazine derivative as an active substance, which is 4-amino-8-ethoxycarbonyl-imidazo[5,1-c][1,2,4]triazine-3-N-cyclohexyl-carboxamide or 4-amino-8-ethoxycarbonyl-imidazo[5,1-c][1,2,4]triazine-3-N-benzylcarboxamide. Use of said agent as a cytotoxic agent for breast cancer chemotherapy.

EFFECT: said group of inventions has higher efficacy compared to epirubicin.

2 cl, 2 dwg, 1 ex