METHOD FOR PREVENTION OF VENOUS THROMBOEMBOLIC COMPLICATIONS IN PATIENTS WITH MALIGNANT NEW GROWTH OF PROSTATE AFTER RADICAL PROSTATECTOMY Russian patent published in 2024 - IPC A61K31/727 A61P7/02 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to prevention of thromboembolic complications in patients with radical prostatectomy. Nadroparin calcium is administered 12 hours before surgery in dose of 0.3 ml — 2,850 IU anti-Xa subcutaneously and after surgery for 7–10 days once a day subcutaneously taking into account the body weight of the patients according to the scheme: body weight less than 70 kg — 0.3 ml, body weight more than or equal to 70 kg — 0.6 ml — 5,700 IU anti-Xa. 8–12 hours after the operation, before the first postoperative administration of nadroparin calcium, a thrombodynamics test is performed, and if the index V is the stationary clot growth rate: greater than or equal to 43 mcm/min, then 12 hours after a dose of nadroparin calcium, calculated for the patient's weight, additionally administering calcium nadroparin in amount of 0.3 ml — 2,850 IU anti-Xa once a day until the day of discharge; less than 43 mcm/min, the treatment is continued according to the above scheme. Further, on the third postoperative day, the thrombodynamics test is repeated 3–4 hours after the administration of the next dose of nadroparin calcium, and if the index V is greater than or equal to 43 mcm/min, then 12 hours after a dose of nadroparin calcium, calculated for the patient's weight, additionally administering calcium nadroparin 0.3 ml — 2,850 IU anti-Xa 1 time a day until the day of discharge, provided that the patient has previously received a dose of nadroparin calcium according to the above regimen; less than 43 mcm/min, the treatment is continued according to the above scheme.

EFFECT: invention enables to prevent the risk of developing venous thromboembolic complications in patients during radical prostatectomy, prevent the development of venous thromboembolic complications and reduce the number of days of hospitalization.

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