METHOD FOR PREDICTION OF RISK OF VENOUS THROMBOEMBOLIC COMPLICATIONS IN SEVERE BURN INJURY Russian patent published in 2020 - IPC A61B5/145 G01N33/49 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to laboratory diagnostics, and can be used for prediction of risk of developing venous thromboembolic complications (VTEC) in severe burn injury. Venous blood sampling is performed with subsequent determination of hemostasis parameters. Patient's venous blood sampling is performed on the first post-traumatic day 1 hour after the beginning of the anticoagulant therapy - introduction of unfractionated heparin to obtain thrombocyte-free plasma and subsequent measurement of the Vi (mcm/min) initial clot growth rate. If the value Vi≥66.1 mcm/min, a high risk of developing VTEC is predicted from 1st to 6th day from the moment of injury. If the initial clot growth rate Vi<66.1 mcm/min is obtained, then, from 6 to 8 days after the trauma, the venous blood is re-sampled in the patient at least 4 hours after the last unfractionated heparin introduction and the initial clot Vi growth rate, the clot steady-state growth rate Vs (mcm/min) and the clot density D (con. units) are measured, and Frank index is also estimated. When obtaining the value Vi≥59.2 mcm/min, Vs≥32 mcm/min and D≥32568 (con. units) with the Frank index more than 30 units, high risk of developing VTEC with a severe burn injury is predicted.

EFFECT: method enables the early prediction of the risk of developing venous thromboembolic complications in the patients with severe burn injury by evaluating the hemostasis system values, which enables to determine the blood coagulation potential in the patients with severe trauma.

1 cl, 1 tbl, 4 ex