FIELD: biotechnology.
SUBSTANCE: invention relates to proteins based on antibodies with a grafted cytokine to activate immune cells, and can be used in medicine to treat cancer. The following is proposed: a fusion protein design based on an antibody containing a heavy chain variable region (VH) and a light chain variable region (VL), in which a mutant interleukin 2 (IL2) molecule is grafted onto HCDR1.
EFFECT: invention provides for production of an immunocytokine with selectivity for activation of CD8+ T-cells with a decrease in the activation of Treg-cells, an increased half-life and effectiveness in the treatment of cancer.
29 cl, 8 dwg, 2 tbl, 8 ex
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