METHOD FOR PREDICTION OF RISK OF RECURRENT DISEASE OF SQUAMOUS CELL LUNG CANCER OF STAGE IIB-IIIA IN PATIENTS RECEIVING ADJUVANT POLYCHEMOTHERAPY AFTER RADICAL SURGERY Russian patent published in 2024 - IPC G01N33/48 A61B5/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and can be used to predict the risk of recurrence in patients with stage IIb–IIIa squamous cell lung cancer, having received adjuvant polychemotherapy after radical surgery. A histological examination of the tumour tissue samples is carried out; in the preparations stained with Mayer's haematoxylin and eosin, the following is determined: presence of vessels in the solid component of the tumour, cell fragmentation in the solid component of the tumour, loose irregular connective tissue in tumour stroma and located in it capillaries of regular shape, lined with cells with nuclei of oval shape with delicate mesh structure of chromatin, which along with low degree of G3 tumour differentiation are considered as factors of unfavourable prognosis. In those cases when three or more of the listed factors are detected in the analysed samples, a high risk of disease recurrence is predicted, and if less than three factors are detected or their absence, a low risk of disease recurrence is predicted.

EFFECT: invention makes it possible to detect groups of patients with squamous cell lung cancer of IIb–IIIa stages with high risk of recurrence of disease and to make adjustments to conducted treatment, and also promotes higher accuracy of disease prediction in order to optimize the conducted treatment; method is easy to implement, does not require additional financial costs and is characterized by high efficiency, sensitivity 78,3%, specificity 86,4%, accuracy 80,9%.

1 cl, 4 ex, 7 dwg