AMHRII BINDING COMPOUNDS FOR PREVENTING OR TREATING CANCER Russian patent published in 2024 - IPC A61K39/395 C07K16/28 G01N33/574 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: presented is the use of a human AMHRII binding agent as an active ingredient for preventing or treating non-gynaecological cancer which expresses AMHRII on the surface of a tumour cell. Agent which binds human AMHRII includes a monoclonal antibody against AMHRII or a fragment thereof which binds AMHRII. Non-gynaecological cancer is colon cancer or liver cancer. Also disclosed is a method for determining patient's sensitivity to cancer treatment using said AMHRII binding agent. Method involves determining the presence of expression by a sample of tumour tissue obtained from a patient, the AMHRII protein on the cell surface. Tumour tissue sample is obtained from non-gynaecological cancer selected from colon cancer and liver cancer. It is determined that the patient is sensitive to the cancer treatment if the said sample demonstrates the presence of AMHRII expression.

EFFECT: invention provides the absence of toxic effects in the process of in vivo treatment of non-gynaecological cancer.

8 cl, 23 dwg, 14 tbl, 7 ex