METHOD FOR DIAGNOSING MALIGNANT TUMORS OF THORACIC CAVITY ORGANS Russian patent published in 2024 - IPC A61B6/00 A61B5/113 G01N33/48 G01N33/497 

FIELD: medicine; thoracic oncology.

SUBSTANCE: invention can be used for lung cancer screening. Determining the exhaled air composition by a non-selective method of analyzing volatile organic compounds with the simultaneous use of metal oxide sensors with cross-sensitivity, in which analysis of volatile organic compounds is carried out using 7 metal oxide chemoresistor gas sensors at sequentially set temperatures of 350, 400 and 450 °C. Sputum cytological analysis is carried out with preparation and microscopic examination of micropreparations, which are stained with hematoxylin and eosin. When detecting statistically significant differences in the response of the sensors to the composition of the exhaled air from the reference values determined in advance for the sensors used, as well as if dysplasia and cancer cells are detected in the micropreparations, low-dose computed tomography is performed on 16-slice tomograph, with a slice width of not more than 1.25 mm, with analysis parameters of 120–140 kVp and 30–100 mAs, performing a three-dimensional reconstruction and an effective dose during one study of not more than 1 mSv. If observing focal changes in the pulmonary parenchyma, a stereotactic transthoracic trephine biopsy is performed under layer-by-layer local anesthesia with automatic biopsy guillotine needles 14–16 G using a robotic system combined with 128-slice computer tomograph.

EFFECT: method provides higher accuracy of non-invasive and minimally invasive early detection of malignant tumors of thoracic cavity organs by a combination of methods for determining the composition of exhaled air, cytological analysis of sputum, computed tomography and transthoracic trephine biopsy.

1 cl, 13 dwg, 3 ex