FIELD: pharmaceutics.
SUBSTANCE: invention relates to compounds of formula (II), where R1–R5, Rx, Ra, Rb, m, n are defined in the patent claim, which inhibit factor XIa or kallikrein, and their pharmaceutically acceptable salts and pharmaceutical compositions. Also disclosed are methods of treating or reducing the risk of thromboembolic complications, stroke, acute coronary syndrome, thromboembolic disorder or atrial fibrillation by inhibiting factor XIa in a patient.
EFFECT: therapeutic compounds and compositions are disclosed.
28 cl, 9 tbl, 221 ex
| Title | Year | Author | Number |
|---|---|---|---|
| THERAPEUTIC COMPOUNDS AND COMPOSITIONS | 2015 |
|
RU2733405C2 |
| BIARILE MONOBACTAM COMPOUNDS AND METHODS OF THEIR APPLICATION FOR TREATMENT OF BACTERIAL INFECTIONS | 2016 |
|
RU2746129C2 |
| CATHEPSIN-CYSTEINE PROTEASE INHIBITORS | 2003 |
|
RU2312861C2 |
| COMPOUNDS OF PYRIDAZINAMIDE AND THEIR USE AS SYNTHETIC SYNECKINASIS INHIBITORS (SYK) | 2013 |
|
RU2627661C2 |
| BENZOTHIAZOLE COMPOUNDS AND METHODS FOR THEIR USE FOR TREATMENT OF NEURODEGENERATIVE DISORDERS | 2018 |
|
RU2778370C2 |
| DERIVATIVES OF HYDROXAMIC ACID, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL OR VETERINARY COMPOSITION BASED ON SAID | 1993 |
|
RU2126791C1 |
| COMPOUNDS AND COMPOSITIONS USED FOR TREATMENT OF NTRK-RELATED DISORDERS | 2016 |
|
RU2744974C2 |
| THERAPEUTIC COMPOUNDS AND COMPOSITIONS | 2019 |
|
RU2813780C2 |
| QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2 NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS AND USE THEREOF | 2012 |
|
RU2610262C2 |
| BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USING SAID COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | 2017 |
|
RU2733402C2 |
