FIELD: medicine.
SUBSTANCE: invention relates to cell technologies and tissue engineering. Disclosed is a method of forming a trabecular bone organoid, which is a three-dimensional self-renewing and self-organizing periosteal microtissue, built on the basis of bioactive demineralised spongy bone matrix and mesenchymal stem cells (MSC), differentiated into osteogenic and angiogenic cells.
EFFECT: disclosed method is applicable in preclinical studies in vitro of promising substances and new drugs for assessing their osteoinductive/osteogenic and endotheliogenic action.
1 cl, 4 dwg
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