THERAPEUTIC COMPOSITIONS OF 4'-HALOGEN-CONTAINING NUCLEOTIDES AND NUCLEOSIDES AND USE THEREOF Russian patent published in 2024 - IPC C07D307/12 C07D239/10 C07D405/04 C07H19/06 C07H19/20 A61K31/505 A61K31/7068 A61K31/7072 A61P31/12 A61P31/14 A61P31/16 

Abstract RU 2819040 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to an oral composition for treating or preventing a viral infection containing a compound of formula XXVIII or compound 1 or 2 specified below, as well as to a method of treating or preventing a viral infection, comprising oral administration of an effective amount of such a composition to a subject in need thereof. In general formula XXVIII R1 is selected from

;

Y is O; R2 is hydroxy; R3 is hydroxy; R6, R6', R6'' and R6''' are each independently selected from hydrogen, hydroxyl, amino, halogen, C1-C10 alkyl or C1-C10 alkoxy.

EFFECT: use of the invention enables to effectively treat viral infections, such as togaviruses, bunyaviruses, arenaviruses, coronaviruses, flaviviruses, picornaviruses, Eastern, Western and Venezuelan equine encephalitis (EEE, WEE and VEE respectively), Chikungunya fever (CHIK), Ebola, influenza, RSV and Zika virus infections.

16 cl, 9 dwg, 1 tbl, 85 ex

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RU 2 819 040 C2

Authors

Pejnter, Dzhordzh R.

Perriman, Devid

Blumling, Gregori R.

Dates

2024-05-13Published

2019-03-07Filed