FIELD: pharmaceutics.
SUBSTANCE: present invention relates to method of producing hybrid microcapsules for drug delivery, during which calcium carbonate particles are obtained, on which a polymer shell is applied, after which an active substance is added to the particles, characterized by that a coating of polyarginine and dextran sulphate layers is applied, wherein the active substance is applied to at least one of the coating layers, besides, glutathione is deposited on at least one of the coating layers, then calcium carbonate nuclei are dissolved, wherein the active substance used is RNA molecules.
EFFECT: present invention reduces the concentration of reactive oxygen species in the obtained microcapsules.
6 cl, 5 dwg, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR TREATMENT OF MALIGNANT NEOPLASMS USING MAGNETIC HYPERTHERMIA AND COMPOSITION FOR APPLICATION IN THIS METHOD | 2020 |
|
RU2792161C2 |
| PEPTIDE-BASED COMPOSITION SUPPRESSING REPLICATION OF INFLUENZA A VIRUS | 2018 |
|
RU2695336C1 |
| METHOD OF PRODUCTION OF POLYELECTROLYTE NANO- AND MICROCAPSULES WITH PROTEIN CONTENT | 2007 |
|
RU2369386C2 |
| METHOD OF LOADING INORGANIC NANOPARTICLES OR ORGANIC MOLECULES INTO POROUS PARTICLES OF MICRON OR SUBMICRON SIZE | 2019 |
|
RU2721562C1 |
| RECOMBINANT STRAIN OF INFLUENZA VIRUS A/PR8-NS124-TB10_4-2A-HSPX AND METHOD FOR SPECIFIC PREVENTION OF PULMONARY TUBERCULOSIS USING MUCOSAL VACCINE BASED THEREON | 2019 |
|
RU2726106C1 |
| RECOMBINANT STRAIN OF A/PR8-NS124-Luc INFLUENZA VIRUS AND METHOD FOR EVALUATING POST-VACCINAL NEUTRALIZING ANTIBODIES USING BIOLUMINESCENT DETECTION | 2019 |
|
RU2759054C2 |
| METHOD TO PRODUCE OXYGEN-ABSORBING ELEMENTS OF PROTECTIVE COATING IN FORM OF MICROCAPSULES | 2009 |
|
RU2422197C2 |
| METHOD FOR PRODUCING MICROCAPSULES FOR DNA DELIVERY TO MACROORGANISM | 2009 |
|
RU2409384C1 |
| RECOMBINANT INFLUENZA VIRUS STRAIN A/PR8/HK-NS80E85A, EXPRESSING FRAGMENTS OF ESAT-6 AND AG85A MYCOBACTERIUM TUBERCULOSIS ANTIGENS, TO OBTAIN TUBERCULOSIS VECTORED VACCINE | 2018 |
|
RU2678175C1 |
| METHOD OF MODIFYING ENVELOPES OF POLYELECTROLYTE CAPSULES WITH MAGNETITE NANOPARTICLES | 2011 |
|
RU2522204C2 |
