METHOD FOR PREDICTION OF POST-LOAD BRONCHOSPASM SYNDROME FORMATION IN PATIENTS WITH MILD BRONCHIAL ASTHMA Russian patent published in 2024 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention can be used in pulmonology. Method for prediction of post-exercise bronchospasm syndrome formation in patients with mild bronchial asthma consists in the fact that before the bronchial challenge test with graduated physical activity (DPA), the content of C-reactive protein (CRP), mg/l, is determined in the venous blood serum, and spirography is used to measure initial forced expiratory volume in the first second (FEV_{1 ref}), l. After the DPN, the maximum change in the forced expiratory volume in the first second, %, of the initial one (ΔFEV_{1 max}) is determined using spirography, by comparing relative changes of FEV₁ after the test at the first minute (ΔFEV_{1 1 min}) and at the tenth minute (ΔFEV_{1 10 min}) as follows: if ΔFEV_{1 1} and ΔFEV_{1 10} have negative values, but higher than −10%, selecting ΔFEV₁, as much as possible different from initial FEV₁, and take it as ΔFEV_{1 max}; if ΔFEV_{1 1} and ΔFEV_{1 10} have positive values, selecting ΔFEV₁ with the least difference from FEV_{1 ref} and taking it as ΔFEV_{1 max}; if one of indicators ΔFEV_{1 1 min} and ΔFEV_{1 10 min} has a positive value, and the other is negative for ΔFEV_{1 max}, the value is taken with negative value, provided that it is higher than −10%. Further, a discriminant equation is used to predict the formation of post-load bronchospasm syndrome: D=+2.107×ΔFEV_{1 max}−1.627×CRP, where D is a discriminant function, the boundary value of which is equal to −22.90. If D is less than the limit value of the discriminant function, post-load bronchospasm syndrome is predicted in the patients with mild bronchial asthma.

EFFECT: invention enables predicting post-load bronchospasm syndrome in the patients with mild bronchial asthma.

1 cl, 2 ex