FIELD: biotechnology.
SUBSTANCE: present invention relates to expression vectors for producing proteins of interest. Invention discloses an expression vector with a weak promoter SIN LTR, which controls expression of a selectable marker.
EFFECT: presence in the structure of the expression vector of such a weak promoter, which is in a functional relationship with a selectable marker, improves ability of cell culture to produce higher titres and provides high specific productivity of protein of interest.
14 cl, 9 dwg, 7 tbl, 6 ex
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