FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing a compound of formula (1) or a salt thereof. Method comprises a step of reacting a compound of formula (2) or a salt thereof and a compound of formula (3) with an alkali metal salt or an alkali salt in the presence of a catalyst based on a complex with a metal to obtain a compound of formula (4) or a salt thereof. Alkali metal salt is K2CO3 and catalyst based on complex with metal is (dtbpf)PdCl2. Then one performs a step of reacting a compound of formula (4) or a salt thereof with a compound of formula (5) to obtain a compound of formula (6) or a salt thereof, and a step of compounding formula (6) with HCl to obtain a compound of formula (1) or a salt thereof. Invention also relates to a embodiment of said method.
EFFECT: disclosed method enables to obtain a compound of formula (1) with higher output and higher purity with fewer by-products and with lower catalyst load.
2 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING ANDROGEN RECEPTOR ANTAGONISTS AND THEIR INTERMEDIATE COMPOUNDS | 2016 |
|
RU2719590C2 |
| METHOD OF SYNTHESIS OF 5-LIPOXYGENASE INHIBITORS HAVING DIFFERENT HETEROCYCLIC SYSTEMS | 2000 |
|
RU2177005C1 |
| METHOD FOR PRODUCING 2-[(3R)-3-METHYLMORPHOLIN-4-YL]-4-(1-METHYL-1H-PYRAZOL-5-YL)-8-(1H-PYRAZOL-5-YL)-1,7-NAFTHYRIDINE | 2019 |
|
RU2802512C2 |
| PIRAZOLOQINOLINE DERIVATIVE | 2012 |
|
RU2605096C2 |
| PYRAZOLE QUINOLINONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION | 2012 |
|
RU2621037C2 |
| AZAINDAZOLE OR DIAZAINDAZOLE DERIVATIVES AS MEDICINE | 2012 |
|
RU2600976C2 |
| COMPOUND WITH STING AGONISTIC ACTIVITY | 2019 |
|
RU2798265C2 |
| SERINE/THREONINE KINASE INHIBITORS | 2013 |
|
RU2650501C2 |
| HETEROCYCLIC COMPOUND | 2018 |
|
RU2791533C2 |
| PYRAZOLO [3,4-C] PYRIDINES AND METHODS OF APPLICATION THEREOF | 2012 |
|
RU2638116C2 |
