METHOD FOR PREDICTION OF RISK OF DEVELOPING PREECLAMPSIA (PE) IN FIRST TRIMESTER OF PREGNANCY Russian patent published in 2024 - IPC A61B10/00 A61B5/21 G01N33/49 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics and gynaecology. Prediction is carried out at 11–14 weeks of pregnancy, while determining the Rh factor of the patient. Average blood pressure is measured at 11–14 weeks, in mm Hg, taking into account the presence or absence of induced premature delivery in the anamnesis, a history of infertility of 5 years or more, each of the indicators is assigned a point indicating the presence of a risk factor – 1 point or its absence – 0 points. Based on the obtained data, determining the value of the regression function beta by the original formula, where X1 is Rh factor: negative – 1, positive – 0; X2 – induced PD in past medical history: presence – 1, absence – 0; X3 – infertility for 5 years and more: presence – 1, absence – 0; X4 is average blood pressure at 11-14 weeks, mm Hg; then risk of developing PE is calculated: p=1-e^beta/(1+e^beta), where e is the base of the natural logarithm, beta is the value of the regression function; and if the p value is less than 0.5, a low degree of risk of developing PE is predicted, with a value of p equal to 0.5 and more, a high degree of risk of developing PE is predicted.

EFFECT: method enables early prediction of PE in pregnant women in the first trimester of pregnancy, higher specificity and accuracy of the method, accessibility and ease of implementation with high sensitivity.

1 cl, 3 ex